Friday, April 1, 2011

What is the minimum or obligatory urine output in a day for healthy kidneys?

The minimum urine output necessary / day = the amount of urine required to excrete "the solute load" consumed each day.

In an average individual the minimum Solute load excreted daily by kidney is 600-800 mOsm/day. As we know in healthy person, the Maximum urine-concentrating capacity of kidneys is 1200 mOsm/L.

We can calculate the Obligatory urine output in healthy individuals.

for 1200 mOsm solute excretion, the min. amount of urine output required is 1 Liter.

for 600 mOsm solute excretion, the min. amount of urine output will be 0.5 Liter.

Therefore, we require a minimum 500ml of obligatory urine output to excrete daily solute load from our body.

New Treatment Buzz for Hepatitis C patients!

Three drug cocktail: Boceprevir + Peg-interferon + Ribavirin (or) Telaprevir + Peg-interferon + Ribavirin has shown promising results in treatment of Hepatitis C patients.

"66% of previously untreated patients treated with the three-drug regimen of boceprevir, peginterferon, and ribavirin cleared the virus for good, compared to 38% of patients treated with peginterferon and ribavirin alone."

In other study in NEJM, 75% of patients treated for "44 weeks achieved sustained viral clearances, compared to 29% of patients who got a second round of peg-interferon and Ribavirin." The results were "similar to those seen in phase III trials of telaprevir."