Thursday, January 20, 2011
Specific drug treatment for Amyotropic Lateral Sclerosis ( ALS ) patients!
Riluzole has been found to increase survival in few studies and is now (as of 2010-11) being used for ALS patients.
Anti-retroviral drugs ( Class NNRTI )
Why HIV patients get many drugs combined for their treatment?
Anti retroviral drugs are given in combination therapy to overcome the viral resistance development.
e.g. NRTIs, NNRTIs, Protease Inhibitors etc.
Class NNTRI drugs include:
1. Nevirapine
2. Efavirenz
3. Delavirdine
Nevirapine: - ( the first drug approved by FDA in US ) Both nucleoside and non-nucleoside RTIs inhibit the same target, the reverse transcriptase enzyme, an essential viral enzyme which transcribes viral RNA into DNA.
Unlike nucleoside RTIs, which bind at the enzyme's active site, NNRTIs bind allosterically at a distinct site away from the active site termed the NNRTI pocket. Nevirapine also has very good central neverous system (CNS) penetration.
Nevirapine is not effective against HIV-2, as the pocket of the HIV-2 reverse transcriptase has a different structure, which confers intrinsic resistance to the NNRTI class.
As all NNRTIs bind within the same pocket, viral strains which are resistant to nevirapine are usually also resistant to the other NNRTIs, efavirenz and delavirdine.
Anti retroviral drugs are given in combination therapy to overcome the viral resistance development.
e.g. NRTIs, NNRTIs, Protease Inhibitors etc.
Class NNTRI drugs include:
1. Nevirapine
2. Efavirenz
3. Delavirdine
Nevirapine: - ( the first drug approved by FDA in US ) Both nucleoside and non-nucleoside RTIs inhibit the same target, the reverse transcriptase enzyme, an essential viral enzyme which transcribes viral RNA into DNA.
Unlike nucleoside RTIs, which bind at the enzyme's active site, NNRTIs bind allosterically at a distinct site away from the active site termed the NNRTI pocket. Nevirapine also has very good central neverous system (CNS) penetration.
Nevirapine is not effective against HIV-2, as the pocket of the HIV-2 reverse transcriptase has a different structure, which confers intrinsic resistance to the NNRTI class.
As all NNRTIs bind within the same pocket, viral strains which are resistant to nevirapine are usually also resistant to the other NNRTIs, efavirenz and delavirdine.
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